Serological diagnosis of untreated early syphilis. Importance of the differences in THA, TPHA, and VDRL test titres.
نویسنده
چکیده
The treponemal haemagglutination (THA) test has been used for 11 years as a routine test for syphilis at a central serology laboratory. Among patients with untreated early syphilis the antibodies detected by the THA test usually appeared later or were of relatively lower titre than those detected by the reagin tests. This finding was confirmed by follow up of patients and by replies to questionnaires and has been incorporated in a computer program. During 1981, using the results obtained on unpaired specimens and minimal other data, 74 of 123 patients who were finally diagnosed as having untreated early syphilis were correctly identified by the computer. Most of those not selected by the computer were patients with early primary syphilis with little or no circulating antibody or with late secondary syphilis with very high titres.
منابع مشابه
Quarterly Mangalore , South India ISSN 0972 - 5997
Presently, the diagnosis of syphilis is dependent mainly on serological tests. The most widely used screening tests for syphilis are the VDRL and the rapid plasma reagin (RPR) and for confirmation, the fluorescent treponemal antibody (FTA) and the treponema pallidum hemagglutination (TPHA) tests. The four alternative modes for diagnosis of syphilis can be a) VDRL + FTA, b) VDRL + TPHA, c) RPR +...
متن کاملSeroreversion of the serological tests for syphilis in the newborns born to treated syphilitic mothers.
BACKGROUND IgG antibodies from mothers adequately treated for syphilis can cross the placenta and appear in the sera of healthy newborns without infection. In such infants, a false diagnosis of congenital syphilis is often made. We have designed a retrospective survey to determine the time of seroreversion of the serological tests for syphilis (STS) in uninfected newborns born to mothers who we...
متن کاملRole of the Venereal Disease Research Laboratory test in the detection of syphilis.
Of 9733 consecutive serological samples received by Portsmouth and Southampton Public Health Laboratories (PHL) and tested for syphilis, 190 (140 from men and 50 from women) gave positive results. Thirty new cases of syphilis were identified. Most sera were tested initially by both a specific antibody test (the Treponema pallidum haemaglutination (TPHA) test) and a cardiolipin test (the Venerea...
متن کاملEnzyme immunoassay for anti-treponemal IgG: screening or confirmatory test?
AIMS To review the performance of the Venereal Diseases Research Laboratory (VDRL) test and the Treponema pallidum haemagglutination assay (TPHA) as a combined screen for syphilis to provide a baseline for assessing screening by anti-treponemal IGG EIA. METHODS Between 1980 and 1987 all serum samples were screened by both VDRL and TPHA tests. The FTA-ABS test was also used in suspected early ...
متن کاملSyphilis serology and HIV infection in Harare, Zimbabwe.
OBJECTIVE To determine the reliability of serological tests in detecting syphilis in a factory worker cohort and examine the impact of concurrent HIV infection on serological tests for syphilis. METHOD Reactions to non-treponemal and treponemal antigens were tested using sera from a cohort of 3401 factory workers in Harare, Zimbabwe. The participants consented to regular testing for syphilis,...
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ورودعنوان ژورنال:
- The British journal of venereal diseases
دوره 59 3 شماره
صفحات -
تاریخ انتشار 1983